Potential New Class of Cancer Drugs Developed in Lab

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New research published in Cancer Cell, Thomas Burris, Ph.D., chair of pharmacology and physiology at Saint Louis University, targets a broad principle that applies to almost every kind of cancer: its energy source.
Potential New Class of Cancer Drugs Developed in Lab
The Saint Louis University study, which was conducted in animal models and in human tumor cells in the lab, showed that a drug developed by Burris and colleagues at Scripps Research Institute can stop cancer cells without causing damage to healthy cells or leading to other severe side effects.The Warburg Effect

Metabolism — the ability to use energy — is a feature of all living things. Cancer cells aggressively ramp up this process, allowing mutated cells to grow unchecked at the expense of surrounding tissue.

“Targeting cancer metabolism has become a hot area over the past few years, though the idea is not new,” Burris said.

Since the early 1900s, scientists have known that cancer cells prefer to use glucose as fuel even if they have plenty of other resources available. In fact, this is how doctors use PET (positron emission tomography) scan images to spot tumors. PET scans highlight the glucose that cancer cells have accumulated.

This preference for using glucose as fuel is called the Warburg effect, or glycolysis.

In his paper, Burris reports that the Warburg effect is the metabolic foundation of oncogenic (cancer gene) growth, tumor progression and metastasis as well as tumor resistance to treatment.

Cancer’s goal: to grow and divide

Cancer cells have one goal: to grow and divide as quickly as possible. And, while there are a number of possible molecular pathways a cell could use to find food, cancer cells have a set of preferred pathways.

“In fact, they are addicted to certain pathways,” Burris said. “They need tools to grow fast and that means they need to have all of the parts for new cells and they need new energy.”

“Cancer cells look for metabolic pathways to find the parts to grow and divide. If they don’t have the parts, they just die,” said Burris. “The Warburg effect ramps up energy use in the form of glucose to make chemicals required for rapid growth and cancer cells also ramp up another process, lipogenesis, that lets them make their own fats that they need to rapidly grow.”

If the Warburg effect and lipogenesis are key metabolic pathways that drive cancer progression, growth, survival, immune evasion, resistance to treatment and disease recurrence, then, Burris hypothesizes, targeting glycolysis and lipogenesis could offer a way to stop a broad range of cancers.

Read more: Potential New Class of Cancer Drugs Developed in Lab http://www.medindia.net/news/potential-new-class-of-cancer-drugs-developed-in-lab-150515-1.htm#ixzz3eWvEU6nL

Theon Pharmaceuticals Ltd :- “WATER” the Best Drink

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Every system of our body depends on water.As water flushes out the toxins from our body.
Lack of water can lead to dehydration i.e. a situation that occurs when there is lack of water in our body.images

It is suggested to drink as much as we can .

Even in winters our water intake is less but we should drink atleast 7-8 glasses in winters too.

Theon: Pharmaceutical Medicine – Specialty Wise

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Backed by our sophisticated infrastructural facility and modern amenities, we manufacture and supply a wide range of Speciality Wise. These are processed with genuine quality ingredients and offer high effectiveness, when consumed.

Antiasthmatics & Allergic Rhinitis

  1. Montelukast Sodium IP
    Levocetrizine Dichloride
  2. Montelukast Sodium IP
    Desloratadine
  3. Montelukast Sodium IP
  4. Deflazacort
  5. Doxofylline
  6. Acebrofylline

Antimalarial Drugs

  1. Artemether
    Lumifantrine

Analgesics / Anti Pyretics / Anti Inflammatory

  1. Lornoxicam
    Thiocolchicoside
  2. Aceclofenac
    Thiocolchicoside
  3. Tranexamic Acid
    Mefenamic Acid
  4. Tranexamic Acid
    Ethamsylate
  5. Diclofenac Sodium
    Paracetamol
    Chlorzoxazone

Osteoarthritis

  1. Diacerein
    Aceclofenac
  2. Diacerein
    Glucosamine Sulphate Potassium Chloride
  3. Diacerein
    Glucosamine Sulphate Potassium Chloride
    Methyl Sulfonyl Methane
  4. Linezolid
  5. Aceclofenac
    Paracetamol
    Serratiopeptidase

Neuropathy

  1. Pregabalin
  2. Gabapentin
    Methylcobalamin
    Memantine
    Donezepil

Theon: Our Commitments

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commitment-ban

At theon, Corporate Ethics take priority over Profit. Theon places paramount importance on respect for life and strives for fair, transparent and ethical corporate activities based on ethical standards

To Business Partners

Based on delivering value to its stakeholders Theon constantly inspires its people to innovate, achieve excellence and set new global benchmarks. Driven by the passion of its more than 500 strong multicultural workforce Theon continues to aggressively pursue its mission of “Enriching lives globally, with quality and affordable pharmaceuticals.”

To Business Partners

Based on delivering value to its stakeholders Theon constantly inspires its people to innovate, achieve excellence and set new global benchmarks. Driven by the passion of its more than 500 strong multicultural workforce Theon continues to aggressively pursue its mission of “Enriching lives globally, with quality and affordable pharmaceuticals.”

To Healthcare Professionals

We are driven by constant goal to discover new medicines, new technologies and new ways to manage health to help people to live healthier lives. Our comprehensive line of products encircles life and addresses important health needs from infancy to golden years.

To Community

Corporate Social Commitment and Public Service is deeply embedded in cultural fabric of Theon. Over years serious efforts have been directed towards making meaningful contribution in uplifting and transforming the lives of underprivileged and the environment. We continue to make serious efforts to promote good health, social development and better environment, through various company programs that contributes all round growth.

To Government

Theon is committed to performing with integrity and acting ethically and legally in accordance with all applicable laws and regulations, including, but not limited to, anti-bribery and anti-corruption laws. We expect the same commitment from our business associates, consultants, agents, representatives or other companies and individuals acting on Theon’s behalf.

Theon: Mission and Vision

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Mission


Theon’s mission is to uphold our social responsibility by improving the quality of human life by providing quality products of WHO-GMP standards and ensuring premier health care for the society. It endeavors to unlock the geographic potential by delivering balanced and improved product portfolio of quality and cost. The company envisages of being a forerunner in the fast emerging and ever growing market.

THEON believes that complete customer satisfaction is the key to increase clientele and expand business. It provides genuine and timely solutions keeping commitments in true spirit. Prompt responsiveness and acceptance of audit compliance is a natural corollary. Passion to excel in technology, competency, resources and services, renders Theon a defined competitive edge over others. The 3 C’s Competence, Connection and Character binds us to our customers.

Vision

As a dynamic, innovative, caring and reliable pharmaceutical company, the vision is to stand out as exemplary performer in national and international arena. Theon wants to excel manufacturing of highest quality products with ethical standards and obligation to do right and fair.

About Theon Pharmaceuticals

theonpharmaceuticalsltd01 Theon Pharmaceuticals , , ,

Quality is a foundation on which the company has built its reputation. Today, we meet or exceed current good manufacturing practices (cGMP) norms and continue to invest in our people, process and equipment to ensure that we remain an industry leader.

We maintain the highest standards of quality; the products meet relevant pharmacopeial standards and statutory requirements. In addition, the company ensures that all the steps involved in design, development and manufacture of a product leads to the intended level of quality performance in the market. This commitment to quality requires us to ensure that our facility is geared up to provide the right environment, our personnel are trained and quality conscious, our packaging provides the requisite security and cosmetic appeal and our products provide complete customer satisfaction.

We, at Theon value the relationships with our esteemed clients and believe in ‘Customer Centricity’ approach and measure our performance on the value delivered to our clientele. We aim at providing genuine and timely solutions keeping commitments in true spirits. Prompt responsiveness and acceptance of Audit compliance is a natural corollary. To its unparalleled service and unsurpassed quality, the company has got all that it takes to sustain its commitment to excellence.